Billy Twelvetrees missed out on a England starting spot after Jonathan Joseph was rewarded for the consistency of his club form.
The Gloucester captain started the final game of the autumn, a 26-17 victory over Australia, but has been demoted to the bench for the opening game of the RBS 6 Nations against Wales on Friday.
Stuart Lancaster has opted for a ninth midfield partnership in three years, pairing Bath's Joseph with Luther Burrell, who played alongside Twelvetrees throughout last year's Championship.
The duo have just 13 caps between them in comparison to Wales' Jamie Roberts, who is starting his 25 consecutive match in the tournament, and Jonathan Davies who boast a combined 107.
But Lancaster is content with the quality of England's back-line ahead of the Cardiff clash.
He said: "Obviously in the back line, there's less experience but there is exciting talent. There's Anthony Watson and Johnny May. They've got wheels on the wings. Certainly Jonathan Joseph deserves his chance with his form for Bath.
"With George Ford and Ben Youngs, we've got a really good balance across the board.
"At centre, there've been reasons why combinations have changed over the last few games. Injuries have played their part. Luther Burrell is back in having been out of the equation in November and Kyle Eastmond, Manu Tuilagi and Brad Barritt are out.
"We're happy with the combination we've got. Luther will bring that gainline physical presence and JJ has been outstanding for Bath over the last six months. They're up against two experienced centres but Burrell and Billy Twelvetrees acquitted themselves well last year at Twickenham."
England have been preparing from the fervent Millennium Stadium crowd by installing loud speakers at their Pennyhill Park training base.
Hymns and Arias could be heard reverberating around the country hotel grounds as the media descended on Bagshot this morning and Lancaster admits it is to ensure his young side can cope with the red-hot atmosphere.
He also confirmed it was his intention to have the Millennium Stadium roof open. Lancaster has the final call as both teams must agree to it being shut and must confirm the decision this evening.
He added: "All it is is a way of trying replicate for the players who haven't been there examples of the type of sounds and how it reverberates around the stadium and how clear your communication has to be.
"Often, you can't hear yourself on the field because of the intensity of the occasion and it just replicates that and gives you a bit of a chance to prepare.
"We've not done it all week, I can assure you, because we'd have no eardrums left!
"We've got a decision to make by the close of play today on the roof. We're waiting for the latest weather forecast but it looks like it's set fair and if it is then we want it open."
