Ireland have been named as the new favourite to win the Six Nations by bookmakers William Hill.
The odds for Joe Schmidt's men have been cut from 2/1 to 15/8.
England are now the second favourites at 2/1 due to injuries to key players such as Owen Farrell and Ben Morgan, with Wales at 3/1.
But it looks very close, with odds of 4/6 that no team manages to win the Grand Slam.
For the opening game on Friday, William hill are offering odds of 4/7 for a Wales win, 6/4 for England, 18/1 for a draw.
"Ireland were the form team of the Autumn Internationals and with England's Injury list growing by the day – punters have piled into Ireland," said William Hill spokesman Rupert Adams.
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